| MedImpact Healthcare Systems 10181 Scripps Gateway Ct. San Diego CA 92131 |
Layoff |
125 |
2026-03-04 |
2026-03-04 |
| The Vons Companies 2345 E. Valley Parkway Escondido CA 92027 |
Closure |
65 |
2026-05-01 |
2026-03-02 |
| Red O La Jolla, LCC 4340 La Jolla Village Drive San Diego CA 92122 |
Closure |
91 |
2026-04-20 |
2026-02-16 |
| LPL Financial 4707 Executive Drive San Diego CA 92121 |
Layoff |
72 |
2026-04-17 |
2026-02-13 |
| Legacy Supply Chain 10031 Old Grove Rd San Diego CA 92120 |
Layoff |
14 |
2026-04-01 |
2026-01-31 |
| Intrepid Studios 3721 Valley Centre Dr., Ste. 200 San Diego CA 92130 |
Closure |
123 |
2026-02-02 |
2026-01-31 |
| Lighteum Medical 12205 World Trade Drive San Diego CA 92128 |
Layoff |
83 |
2026-04-03 |
2026-01-30 |
| Amazon 13x in 12 mo 10300 Campus Point Dr. Ste. 200 San Diego CA 92121 |
Layoff |
38 |
2026-04-28 |
2026-01-29 |
| Amazon 13x in 12 mo 17075 Camino San Bernardo San Diego CA 92127 |
Layoff |
1 |
2026-04-28 |
2026-01-29 |
| Amazon 13x in 12 mo 4575 La Jolla Village San Diego CA 92122 |
Layoff |
19 |
2026-04-28 |
2026-01-29 |
| Amazon 13x in 12 mo Wework Aventine San Diego CA 92122 |
Layoff |
13 |
2026-04-28 |
2026-01-29 |
| Amazon 13x in 12 mo 4577 La Jolla Village San Diego CA 92122 |
Layoff |
2 |
2026-04-28 |
2026-01-29 |
| Amazon 13x in 12 mo 6971 Otay Mesa Road San Diego CA 92154 |
Layoff |
1 |
2026-04-28 |
2026-01-29 |
| Catholic Charities, Diocese of San Diego 5x in 12 mo 3131 Camino Del Rio N, Ste. 300 San Diego CA 92108 |
Layoff |
45 |
2026-03-31 |
2026-01-27 |
| Catholic Charities, Diocese of San Diego 5x in 12 mo 4575 Mission Gorge Place San Diego CA 92120 |
Layoff |
7 |
2026-03-31 |
2026-01-27 |
| Catholic Charities, Diocese of San Diego 5x in 12 mo 4575 Mission Gorge Place San Diego CA 92120 |
Layoff |
11 |
2026-03-31 |
2026-01-27 |
| Catholic Charities, Diocese of San Diego 5x in 12 mo 4902 Pacific Highway San Diego CA 92110 |
Layoff |
7 |
2026-03-31 |
2026-01-27 |
| Catholic Charities, Diocese of San Diego 5x in 12 mo 3888 Paducah Dr. San Diego CA 92117 |
Layoff |
6 |
2026-03-31 |
2026-01-27 |
| Thermo Fisher Scientific 3x in 12 mo 5781 Van Allen Way Carlsbad CA 92008 |
Layoff |
173 |
2026-03-18 |
2026-01-27 |
| Gilead Sciences 3x in 12 mo 4010 Ocean Ranch Blvd Oceanside CA 92056 |
Layoff |
34 |
2026-03-27 |
2026-01-21 |
| Best Buy 11160 Rancho Carmel Dr. San Diego CA 92128 |
Closure |
46 |
2026-03-17 |
2026-01-16 |
| Primo Brands 11811 Highway 67 Lakeside CA 92040 |
Layoff |
19 |
2026-03-17 |
2026-01-16 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
1 |
2026-03-09 |
2026-01-14 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
4 |
2026-03-16 |
2026-01-14 |
| Macy's 5500 Grossmont Center Drive La Mesa CA 91942 |
Closure |
77 |
2026-03-18 |
2026-01-09 |
| Cucina Enoteca Del Mar 2730 Via de la Valle Del Mar CA 92014 |
Layoff |
43 |
2026-03-11 |
2026-01-09 |
| FormFactor 2281 Las Palmas Dr. Carlsbad CA 92011 |
Closure |
107 |
2026-12-18 |
2026-01-06 |
| Copan Diagnostics 2728 Loker Avenue West Carlsbad CA 92010 |
Closure |
79 |
2026-03-13 |
2026-01-05 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
1 |
2025-12-22 |
2025-12-22 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
7 |
2025-12-08 |
2025-12-11 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
3 |
2026-02-17 |
2025-12-04 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
7 |
2026-01-19 |
2025-11-20 |
| Blue Shield of California 3x in 12 mo 3131 Camino Del Rio North, Suite #1300 San Diego CA 92108 |
Layoff |
1 |
2026-01-27 |
2025-11-18 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
8 |
2025-11-11 |
2025-11-13 |
| Gilead Sciences 3x in 12 mo 4010 Ocean Ranch Blvd Oceanside CA 92056 |
Layoff |
17 |
2026-01-16 |
2025-11-12 |
| The French Gourmet 960 Turquoise St. San Diego CA 92109 |
Closure |
102 |
2026-01-01 |
2025-11-07 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
28 |
2026-01-05 |
2025-11-06 |
| Illumina 9x in 12 mo 5200 Illumina Way San Diego CA 92122 |
Layoff |
4 |
2026-01-05 |
2025-11-05 |
| Becton, Dickinson 3750 Torrey View Court San Diego CA 92130 |
Layoff |
59 |
2025-10-01 |
2025-10-31 |
| Becton, Dickinson 10020 Pacific Mesa Boulevard San Diego CA 92121 |
Layoff |
7 |
2025-10-01 |
2025-10-31 |
| Infineon 1212 Scripps Summit Drive, Suite 300 San Diego CA 92131 |
Layoff |
3 |
2025-11-14 |
2025-10-31 |
| Louis Vuitton USA 4545 La Jolla Village Drive, Space 2500 San Diego CA 92122 |
Closure |
9 |
2026-01-25 |
2025-10-28 |
| Amazon 13x in 12 mo 10300 Campus Point Dr Ste 200 San Diego CA 92121 |
Layoff |
24 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo 17075 Camino San Bernardo San Diego CA 92127 |
Layoff |
50 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo 4575 La Jolla Village San Diego CA 92122 |
Layoff |
61 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo Wework Aventine San Diego CA 92122 |
Layoff |
3 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo 4577 La Jolla Village San Diego CA 92122 |
Layoff |
5 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo 6971 Otay Mesa Road San Diego CA 92154 |
Layoff |
1 |
2026-01-26 |
2025-10-28 |
| Amazon 13x in 12 mo 7144 Otay Mesa Rd San Diego CA 92154 |
Layoff |
1 |
2026-01-26 |
2025-10-28 |
| WIS International 9635 Granite Ridge Drive, Suite 250 San Diego CA 92123 |
Layoff |
10 |
2026-01-01 |
2025-10-27 |
| WIS International 9265 Sky Park Court San Diego CA 92123 |
Layoff |
10 |
2026-01-01 |
2025-10-27 |
| San Diego Imaging 765 Medical Center Court, STE. 101 Chula Vista CA 91911 |
Layoff |
63 |
2025-12-29 |
2025-10-23 |
| San Diego Imaging 7910 Frost Street, Suite 100 San Diego CA 92123 |
Layoff |
32 |
2025-12-29 |
2025-10-23 |
| Blue Shield of California 3x in 12 mo 3131 Camino Del Rio, Suite #1300 San Diego CA 92108 |
Layoff |
4 |
2025-12-02 |
2025-10-13 |
| Hilton San Diego Bayfront 1 Park Boulevard San Diego CA 92101 |
Layoff |
394 |
2025-12-13 |
2025-10-12 |
| Ballast Point Brewing 9405 Carroll Way San Diego CA 92121 |
Closure |
29 |
2025-12-15 |
2025-10-08 |
| Ballast Point Brewing 2215 India Street San Diego CA 92121 |
Closure |
8 |
2025-12-15 |
2025-10-08 |
| Kaiser Permanente 8954 Rio San Diego Dr. San Diego CA 92108 |
Layoff |
1 |
2025-09-17 |
2025-10-06 |
| CRC ED Treatment, Montecatini 3x in 12 mo 2524 La Costa Avenue Carlsbad CA 92009 |
Closure |
79 |
2025-11-08 |
2025-09-09 |
| CRC ED Treatment, Montecatini 3x in 12 mo 6183 Paseo Del Norte, Suite 110 Carlsbad CA 92011 |
Closure |
5 |
2025-11-08 |
2025-09-09 |
| CRC ED Treatment, Montecatini 3x in 12 mo Remote Carlsbad CA 92009 |
Closure |
3 |
2025-11-08 |
2025-09-09 |
| The Brigantine 10514 Craftsman Way San Diego CA 92127 |
Closure |
64 |
2025-11-04 |
2025-09-04 |
| Sandpiper 2259 Avenida De La Playa La Jolla CA 92037 |
Closure |
25 |
2025-11-04 |
2025-09-03 |
| Epic Lightning Fast Service 5670 Kearny Mesa Rd. San Diego CA 92111 |
Closure |
116 |
2025-10-31 |
2025-09-01 |
| Dexcom 6290-6350 Sequence Drive San Diego CA 92121 |
Layoff |
319 |
2025-11-03 |
2025-08-27 |
| TriLink Biotechnologies 4x in 12 mo 10770 Wateridge Cir. San Diego CA 92121 |
Layoff |
69 |
2025-10-06 |
2025-08-08 |
| TriLink Biotechnologies 4x in 12 mo 5717 Pacific Center Blvd. San Diego CA 92121 |
Layoff |
5 |
2025-10-06 |
2025-08-08 |
| TriLink Biotechnologies 4x in 12 mo 10240 Flanders Ct. San Diego CA 92121 |
Layoff |
5 |
2025-10-06 |
2025-08-08 |
| TriLink Biotechnologies 4x in 12 mo 10247 Flanders Ct. San Diego CA 92121 |
Layoff |
11 |
2025-10-06 |
2025-08-08 |
| Gilead Sciences 3x in 12 mo 4010 Ocean Ranch Blvd Oceanside CA 92056 |
Layoff |
5 |
2025-10-10 |
2025-08-06 |
| Southwest Key Programs 1160 Broadway El Cajon CA 92021 |
Closure |
5 |
2025-10-05 |
2025-08-06 |
| Children's Specialists of San Diego 7910 Frost Street San Diego CA 92123 |
Layoff |
55 |
2025-10-31 |
2025-07-31 |
| Poseida Therapeutics 9390 Towne Centre Dr., #200 San Diego CA 92121 |
Layoff |
52 |
2025-10-01 |
2025-07-31 |
| Southwest Key Programs 1160 Broadway El Cajon CA 92021 |
Layoff |
116 |
2025-07-31 |
2025-07-31 |
| Coastal Trading Ventures 1005 Jamacha Blvd. Spring Valley CA 91978 |
Closure |
27 |
2025-09-30 |
2025-07-29 |
| Thermo Fisher Scientific 3x in 12 mo 5823 Newton Dr Carlsbad CA 92008 |
Layoff |
52 |
2025-09-15 |
2025-07-29 |
| Thermo Fisher Scientific 3x in 12 mo 5781 Van Allen Way Carlsbad CA 92008 |
Layoff |
33 |
2025-09-15 |
2025-07-29 |
| Kaiser Permanente 11975 El Camino Real, Ste. 105 San Diego CA 92130 |
Layoff |
1 |
2025-07-28 |
2025-07-28 |
| SSP America 3325 N. Harbor Dr 6900 Airport Blvd San Diego CA 92101 |
Layoff |
116 |
2025-09-22 |
2025-07-21 |
| Leah's Pantry 2204 Garnet Avenue, Suite 304 San Diego CA 92109 |
Layoff |
40 |
2025-09-30 |
2025-07-16 |
| Blue Shield of California 3x in 12 mo 3131 Camino Del Rio, SUite #1300 San Diego CA 92108 |
Layoff |
2 |
2025-09-23 |
2025-07-14 |
| SenDx Medical 1945 Palomar Oaks Way Carlsbad CA 92011 |
Closure |
119 |
2025-09-15 |
2025-07-10 |
| Pacira BioSciences 10450 Science Center Dr San Diego CA 92121 |
Layoff |
71 |
2025-09-07 |
2025-07-09 |
| Best Buy Health 2200 Faraday Ave, Ste. 100 Carlsbad CA 92008 |
Closure |
161 |
2025-09-12 |
2025-07-08 |
| San Diego LGBT Community Center 8x in 12 mo 3909 Center St San Diego CA 92103 |
Layoff |
60 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 1640 Broadway San Diego CA 92101 |
Layoff |
7 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 1045 11th Ave. San Diego CA 92101 |
Layoff |
6 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 3636 5th Ave., Suite 300 San Diego CA 92103 |
Layoff |
20 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 3878 Old Town Ave. San Diego CA 92110 |
Layoff |
3 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 514 Pennsylvania Ave. San Diego CA 92103 |
Layoff |
2 |
2025-07-07 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 1807 Robinson Ave., Suite 106 San Diego CA 92103 |
Layoff |
5 |
2025-09-06 |
2025-07-03 |
| San Diego LGBT Community Center 8x in 12 mo 3851 Rosecrans St. San Diego CA 92110 |
Layoff |
1 |
2025-09-06 |
2025-07-03 |
| Coastal Trading Ventures 10605 Jamacha Blvd Spring Valley CA 91978 |
Layoff |
74 |
2025-09-07 |
2025-07-02 |
| Republic National Distributing 3602 Kurtz Street San Diego CA 92110 |
Closure |
80 |
2025-09-02 |
2025-07-01 |
| Sharp HealthCare 6x in 12 mo 8695 Spectrum Center Blvd. San Diego CA 92123 |
Layoff |
244 |
2025-09-02 |
2025-06-30 |
| Sharp HealthCare 6x in 12 mo 751 Medical Center Court Chula Vista CA 91911 |
Layoff |
34 |
2025-09-02 |
2025-06-30 |
| Sharp HealthCare 6x in 12 mo 250 Prospect Place Coronado CA 92118 |
Layoff |
1 |
2025-09-02 |
2025-06-30 |
| Sharp HealthCare 6x in 12 mo 5555 Grossmont Center Dr. La Mesa CA 91942 |
Layoff |
40 |
2025-09-02 |
2025-06-30 |
| Sharp HealthCare 6x in 12 mo 7901 Frost Street San Diego CA 92123 |
Layoff |
62 |
2025-09-02 |
2025-06-30 |
| Sharp HealthCare 6x in 12 mo 5651 Copley Dr., Suite A San Diego CA 92111 |
Layoff |
13 |
2025-09-02 |
2025-06-30 |